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| Christopher
Calderone |
Assistant Professor
Olin-Rice 210
(651) 696-6771 office
ccalder2@macalester.edu
Professor Calderone’s research focuses on the enzymology of natural
product biosynthesis. Natural products are a rich source of
valuable compounds that include antibiotics, anticancer agents, and
other therapeutics. However, it is often difficult or impossible
to modify the structures of natural products to increase their
effectiveness or lower their toxicity. By increasing our
understanding of the pathways by which natural products are generated,
the ultimate goal of Professor Calderone’s research is to allow the
engineering of modified products with desired properties.
Professor Calderone was recently awarded a Dreyfus Foundation Faculty
Start-Up Award in support of these efforts.
Current Courses:
BIOL351L
Biochemistry Lab
Education:
BS University of Chicago, 1999
MPhil Cambridge University, 2001
PhD Harvard University, 2005
Research Interests:
Enzymology, Natural products, Biosynthesis, Secondary metabolism
Selected
Publications:
Calderone CT, Bumpus SB, Kelleher NL, Walsh CT, Magarvey NA (2008)
A ketoreductase domain in the PksJ protein of the bacillaene assembly
line carries out both α- and β-ketone reduction during chain growth.
PNAS 105: 12809-12814.
Calderone CT (2008) Isoprenoid-like alkylations in
polyketide biosynthesis. Natural Product Reports 25: 845-853.
Bumpus SB, Magarvey NA, Kelleher NL, Walsh CT, Calderone CT (2008)
Polyunsaturated fatty-acid-like trans-enoyl
reductases utilized in polyketide biosynthesis. J Am Chem Soc 130:
11614-11616.
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