Vagus Stimulation for
Bulimia
Vagus Nerve Stimulation
Based on the findings in Faris’s last study that the vagus nerve
does play some role in the perpetuation of bulimia nervosa and that
treatment directed at the vagus nerve seems to lead to a decrease in
bulimic behaviors, Faris is now trying to see if using a vagus nerve
stimulator can, in effect, retrain the vagus nerve to act properly.
(from http://www.rch.org.au/cep/treatments/index.cfm?doc_id=3245)
The stimulator is about the same size as a silver dollar and is placed
surgically below the clavicle. A small wire from the generator (stimulator)
is threaded from the generator and wrapped around the vagus nerve on
the left side of the neck. The end of the wire that is wrapped around
the vagus nerve is has small electrodes that send pulses directly to
the nerve. The generator then acts as a sort of pacemaker that regulates
the vagus nerve activity. The surgery is outpatient and it takes about
ten hours, however, patients involved in the study are kept overnight

(Image from http://www.marketwire.com/mw/release_html_b1?release_id=7472)
After about two weeks of recovery, the patients and researchers spend
two weeks adjusting the stimulation of the generator so that it is comfortable
and effective for patients. The patient then spends the next eight weeks
with constant stimulation that was found to be effective during the
adjustment period. Simulation occurs every five minutes with thirty
seconds of pulsing (electrical stimulation of the vagus nerve) and then
a rest period of five minutes. If the patient wants to turn off the
stimulator, they can run a magnet over the generator. However, if they
feel an urge to binge or purge they can again place a magnet over the
generator, which will then deliver an extra pulse to the vagus nerve.
This is empowering to the patient because they are able to feel like
they have control over their behavior. The purpose of this study is
an attempt to retrain the vagus nerve so that it may work properly and
the stimulator/ generator does this by regulating the activity of the
vagus. This procedure seems to be the most effective treatment option
to date that targets the vagus nerve because it can allow for direct
and consistent vagal stimulation. The current findings of this research
has yet to be published, but the prospects of this new treatment are
hopeful in decreasing or eliminating bulimic behaviors/ episodes.
(image from http://www.emedicine.com/neuro/topic/599.htm)
Subsections:
Stimulation of the Vagus Nerve in the
Treatment of Bulimia Nervosa
Rationale Behind Research Involving the
Vagus Nerve in the Treatment of Bulimia Nervosa
Ondansetron
Patients
Results
Vagus Nerve Stimulation (top of this
page)