By | Nicole Miller ’14
Biology (biochemistry/molecular biology emphasis)
My interest was sparked in genetics class when Professor Mary Montgomery described RNA interference (RNAi), a Nobel prize-winning discovery that she participated in as a post-doctorate. RNAi is a pathway through which double-stranded RNA can inhibit gene expression. I was fascinated by the complexity and excited to investigate the regulation of genes through RNAi by working with Professor Montgomery.
The human genome contains many repeated genes that must be silenced so that they do not insert into other genes and cause diseases. Human genetics is complex, so it is helpful to gain a basic understanding of silencing mechanisms by studying other organisms.
In Professor Montgomery’s lab we worked with microscopic worms, Caenorhabditis elegans. Experiments are conducted using strains of C. elegans carrying green fluorescent protein (GFP) genes. In strains carrying a single GFP gene, the C. elegans germ line glows green under fluorescent light. However, in a strain possessing multiple copies of the GFP gene on another chromosome, no fluorescence is observed.
I forged new connections with my co-workers as part of a research team and in the span of 10 weeks, I learned to use new equipment, design experiments, evaluate data and troubleshoot problems, all under the guiding hand of an experienced researcher.
February 12 2014Back to top
More Internships News
Seven fledgling businesses spread their wings in a remarkable entrepreneurial incubator.
September 12 2016
Learning the Ropes
From caring for zebras to managing actors, Mac students gained some unforgettable experiences last summer.
September 5 2016
A Semester in French Publishing
A Mac student's literary adventure living and working in France.
July 11 2016
International studies major Emily Elkins ’16 helps refugees become U.S. citizens.
July 4 2016
Math major handles big data in U of Minnesota program designed to find out more about Parkinson's Disease
June 20 2016
Working in a Senator's Office
As a health policy intern, Tess Van Schepen '16 became part of a community in Senator Al Franken's St. Paul office.
June 14 2016
Public Health Internships
Four students talk about their Twin Cities internships in the world of public health.
May 9 2016
Training Ground for After Mac
A peek into the world of legislative government was an opportunity that William Theriac '16 couldn't pass up.
April 25 2016
Internships in Global Issues
Mac students learn about international issues by partnering with local organizations.
April 1 2016
From Intern to Employee
With the support of the Macalester network, Haroon Bokhari '16 landed an investment banking job at Wells Fargo.
March 28 2016
Determined to find a challenging study away experience, Kendall Van Sistine ’16 spent a semester in Ho Chi Minh City.
March 21 2016
From Macalester to Mayo
Her courses, along with her Department of Health experience, helped Alese Halvorson land a job at the famed Mayo Clinic.
March 16 2016