By | Nicole Miller ’14
Biology (biochemistry/molecular biology emphasis)
My interest was sparked in genetics class when Professor Mary Montgomery described RNA interference (RNAi), a Nobel prize-winning discovery that she participated in as a post-doctorate. RNAi is a pathway through which double-stranded RNA can inhibit gene expression. I was fascinated by the complexity and excited to investigate the regulation of genes through RNAi by working with Professor Montgomery.
The human genome contains many repeated genes that must be silenced so that they do not insert into other genes and cause diseases. Human genetics is complex, so it is helpful to gain a basic understanding of silencing mechanisms by studying other organisms.
In Professor Montgomery’s lab we worked with microscopic worms, Caenorhabditis elegans. Experiments are conducted using strains of C. elegans carrying green fluorescent protein (GFP) genes. In strains carrying a single GFP gene, the C. elegans germ line glows green under fluorescent light. However, in a strain possessing multiple copies of the GFP gene on another chromosome, no fluorescence is observed.
I forged new connections with my co-workers as part of a research team and in the span of 10 weeks, I learned to use new equipment, design experiments, evaluate data and troubleshoot problems, all under the guiding hand of an experienced researcher.
February 12 2014Back to top
More Internships News
Training Ground for After Mac
A peek into the world of legislative government was an opportunity that William Theriac '16 couldn't pass up.
April 25 2016
Internships in Global Issues
Mac students learn about international issues by partnering with local organizations.
April 1 2016
From Intern to Employee
With the support of the Macalester network, Haroon Bokhari '16 landed an investment banking job at Wells Fargo.
March 28 2016
Determined to find a challenging study away experience, Kendall Van Sistine ’16 spent a semester in Ho Chi Minh City.
March 21 2016
From Macalester to Mayo
Her courses, along with her Department of Health experience, helped Alese Halvorson land a job at the famed Mayo Clinic.
March 16 2016
NASA Goddard Space Flight Center
Ned Molter '15 puts his research and scientific writing skills to work at NASA Goddard Space Flight Center.
March 2 2016
Green Architecture Intern
When David Weiss interned with Locus Architecture, he saw how concepts from his environmental studies classes were applied in construction and remodeling.
February 29 2016
Human Rights Path
Zoe Bowman '16 explains how she chose a human rights concentration.
February 29 2016
Evelyn Pugh ’19 was one of ten high schoolers who put together The Best American Nonrequired Reading of 2015.
February 23 2016
Internships in the arts have helped three students realize that one can build a career in the art world.
February 8 2016
If you are a student with a gift for analysis, there are a wide variety of internship opportunities in the Twin Cities.
January 27 2016
Young Alumni Entrepreneurs
Young alumni create new enterprises by combining ideas, initiative, and determination.
January 18 2016