Physical Features
- taken orally
- odorless
- colorless
- tasteless
LSD in the body
- half life 110 min in humans
- 35 micrograms can cause measurable effects
- never been linked to one human overdose death
- in rats 400 times the effective dose is lethal
- absorbed in GI tract
- metabolized in liver
- secreted through digestive system as inactive 2-oxy-lysergic acid diethylamide
- effects begin 30-90 min after ingestion
- 1% reaches the brain- not selectively taken up by brain
- tolerance develops rapidly in humans. If taken repeatedely effects disappear in 2 or 3 days, therefore no amount of drug will be effective at this time
- recovery also rapid, same dose as effective week after week
- no withdrawal symptoms have been found
- in laboratory studies most animals will not self-administer LSD, most will work to avoid administration
- taken episodically
Side Effects
- may stimulate sympathetic nervous system
- few physical side effects
- pupils dialate
- increase pulse rate
- increase blood pressure
- increase salivation
- increase body temperature
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