Studies have shown that monkeys and rodents with low MAO-B levels have shown more active and playful behavior. They also slept less than monkeys with high MAO levels.

Blood from the umbilical cords of humans was used to measure MAO-B levels of infants. The infants with low MAO levels were fussier and motor activity was higher than those with normal levels. The MAO levels in infants was inversely related to emotional activity during its first three days after birth.

Low platelet MAO activity is generally associated with restlessness and less inhibition.

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