Panic disorder is a mental illness which causes sudden discrete attacks of intense fear or discomfort. The episodes are unpredictable and often result in breathlessness, faintness, palpitations, nausea or choking sensations. Other symptoms include derealization, chest pain, and fear of death or loss of control.

Current treatments include psychotherapy, tricyclic antidepressants, traditional monoamine oxidase inhibitors (MAOIs), and benzodiazepines. The classic MAOI's are effective, but have very low rates of compliance because of the severe dietary restrictions that accompany their use. For this reason researchers have explored the use of reversible and selective MAO-A inhibitors in the treatment of panic disorder. They are effective in the treatment of depressive illness, and produce minimum side effects. Garcia-Borregueuro et al. studied the effects of brofaromine, one of the reversible and selective MAO-A inhibitors, on patients with panic disorder. The results of this study proved brofaromine to have a statistically significant superior effect over the placebo.

Learning more about anxiety disorders

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