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Tricyclics: History of use and treatment  Imipramine, the first Tricyclic antidepressant, was discovered in 1950 by clinicians searching for new antipsychotics. After years of careful testing, researchers noticed that while these drugs failed to reduce the symptoms of schizophrenia, they did possess antidepressant properties. The drugs were marketed as antidepressants in the 1960s. While they were some of the earliest antidepressants released, they now play second fiddle to the much safer SSRIs. |