Well, one of those connection moments happened to me when we had our real clinical neurology exams a week or so ago. Our first patient was brought in by her daughter after she had suffered a seizure. The lady also presented with some relatively short-term memory loss, and a definite paranoia. She thought that there was a conspiracy going on between the CIA and her daughter, and that the CIA had been the ones to convince her daughter to bring her in. Actually, she wasn't even convinced that it was her daughter. She told us that it was someone who was claiming to be her daughter. Further, she thought that at night, CIA agents would sneak into her studio and mix up the order of her paints.
The memory loss and lack of identifying her daughter pointed us towards Alzheimer's, but some of her other symptoms left us questioning that (like the seizure). However, when she told us that she felt agents were sneaking in and mixing up her paints, I became convinced that she did indeed have Alzheimer's.
The reason her CIA/paints story convinced me is that my grandfather suffered from Alzheimer's when I was younger, and he exhibited similar symptoms. He swore that little men snuck into his garage and basement at night and mixed up his tools; that was why he could never find any of them. The similarity between his idea and the one presented in our patient was striking.