Early-Onset
Extrapyramidal Side Effects (EPSE)
Early-onset extrapyramidal side effects
are drug-induced
involuntary muscle contraction. There are several types of EPSE:
(1) Dystonic
Reactions
- Dystonic
reactions are involuntary contractions of
skeletal
muscles (Lee 1979, in Perry 2001).
- Dystonias commonly
involve the muscles of the head and face, producing spasms of the
mouth, oculogyric
crisis, facial grimacing, tics, or contraction of the
muscles of mastication (trismus). When the neck
is affected, the result
is torticollis or retrocollis.
- The
trunk and the limbs may also be
affected.
- Dystonia may cause
chipped teeth, dislocation of the jaw, and tongue
injuries.
- 72% of patients
affected develop as simple dystonias
(affecting one muscle group only).
- dytoinias
that combine more than two muscle groups are observed in 28% of patients (Lee 1979, in Perry 2001).
To read more about
Dystonia visit http://www.mayoclinic.com/health/dystonia/DS00684
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(2) Akathiasia
- Akathisia is the
subjective experience of motor restlessness such as
inability to sit or stand still, or the compulsive
need to pace or cross and uncross the legs (Tarsy 1983, Van Putten et
al 1984, in Perry 2001). Patients also experience the need to be in
constant motion.
- Insomnia may also be
part of these effects, especially because patients
cannot lie in bed for long enough to fall asleep.
- 90% of patients with
akathisia develop these effects within the first 73 days of treatment
and 50% within the first month (Ayd 1961, in Perry 2001).
To read more about
akathisia visit http://www.biopsychiatry.com/akathisia.htm
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(3)
Parkinsonism
- Parkinsonian
side effects include tremor and rigidity. These symptom may
occur individually or in combination (Tarsy 1983, in
Perry 2001). Drooling, affected gait and oily skin may also be
developed.
- Akinesia
(lack of movement) may develop from as slowness in initiating movement
and fatigue when doing repetitive
movements (bradykinesia). For this reason,
someone with parkinsonian side effects may appear
apathetic because they have little facial expression, walk with
difficulty, and develop cramped
handwriting (micrographia).
- Tremor may be present
both during movement and at rest. It usually originates s in one arms.
- As other EPSE,
parkinsonian side effects are dose-related. However, it is also known
that older patients are at higher risk.
To read more about
parkisonism visit http://www.hsph.harvard.edu/Organizations/ddil/parkins.html
For further information about
EPSE visit http://www.vh.org/adult/provider/psychiatry/CPS/07.html