CURRICULUM VITAE

MARY K. MONTGOMERY

 

Macalester College

Biology Department

1600 Grand Avenue

St. Paul, MN   55105

(651) 696-6425 (office)

(651) 696-8174 (lab)

email: montgomery@macalester.edu

website: http://www.macalester.edu/~montgomery/

 

I. EDUCATION

 

Post-Doc         Developmental Biology                                         1994-1998

                        Carnegie Institution of Washington, Department of Embryology

                        Advisor: Dr. Andrew Fire

 

Ph.D.               Biological Sciences                                               1993

                        University of Southern California, Los Angeles, CA

                        Dissertation:                         Development of the symbiotic light organ of Euprymna scolopes   Berry (Cephalopoda: Sepiolidae)

                        Advisor: Dr. Margaret McFall-Ngai

 

B.A.                 Biology (with honors)                                           1986

                        Immaculata College, PA

 

II. ACADEMIC EMPLOYMENT

 

Full-Time Appointments

 

1998- present        Macalester College, Biology Department, Assistant Professor

 

Part-Time Visiting Appointment

 

Fall 1997               Johns Hopkins University, Dept. of Biological Sciences, Instructor

 

 

III. PUBLICATIONS

 

Peer-Reviewed Research Articles

 

                
  1. Montgomery, MK, S Xu, A Fire (1998)   RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans.   Proc Natl Acad Sci   95: 15502-15507.
  2. Montgomery, MK and M McFall-Ngai (1998)   Late postembryonic development of the symbiotic light organ of Euprymna scolopes.   Biological Bulletin (MBL, Woods Hole, MA)  195: 326-36.
  3. Fire, A, S Xu, MK Montgomery, S Kostas, S Driver and C Mello (1998)   Potent and specific genetic interference mediated by double-stranded RNA in Caenorhabditis elegans .   Nature   391: 806-811.
  4. Kelly, WG, S Xu, MK Montgomery and A Fire (1997)   Distinct requirements for somatic and germline expression of a generally expressed Caenorhabditis elegans gene.   Genetics   146: 227-238.
  5. Mickey, KM, CC Mello, MK Montgomery, A Fire and JR Priess (1996)   An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.   Development   122(6):  1791-1798.
  6. Montgomery, MK and P Kremer (1995)   Transmission of symbiotic dinoflagellates through the sexual cycle of the host scyphozoan Linuche unguiculata .   Marine Biology   124: 147-155.
  7. Montgomery, MK and M McFall-Ngai (1994)   Bacterial symbionts induce host organ morphogenesis during early postembryonic development of the squid Euprymna scolopes.    Development   120: 1719-1729.
  8. Montgomery, MK and M McFall-Ngai (1993)   Embryonic development of the light organ of the sepiolid squid Euprymna scolopes Berry.   Biological Bulletin (MBL, Woods Hole, MA) 184: 296-308.
  9. Weis, VM, MK Montgomery and M McFall-Ngai (1993)   Enhanced production of an ALDH-like protein in the bacterial light organ of the sepiolid squid Euprymna scolopes .   Biological Bulletin (MBL, Woods Hole, MA) 184: 309-321.
  10. Montgomery, MK and M McFall-Ngai (1992)   The muscle-derived lens of a squid bioluminescent organ is biochemically convergent with the ocular lens.   Evidence for recruitment of aldehyde dehydrogenase as a predominant structural protein.  Journal of Biological Chemistry   267: 20999-21003.
  11. McFall-Ngai, M and MK Montgomery (1990)   The anatomy and morphology of the adult bacterial light organ of Euprymna scolopes Berry (Cephalopoda: Sepiolidae).  Biological Bulletin (MBL, Woods Hole, MA) 179: 332-339.

 

Book Chapters and Review Articles

 

  1. Montgomery, MK (in press) RNAi: Historical overview and significance.   Book chapter for RNA interference, editing, and modification (J. Gott, Ed) in Methods in Molecular Biology series, Humana Press: New York.
  2. Montgomery, MK (in press) The use of double-stranded RNA to knock down specific gene activity.   Book chapter for Mobile Genetic Elements: Protocols and Genomic Applications (W. Miller, Ed.) in Methods in Molecular Biology series, Humana Press: New York.
  3. Norman, J and MK Montgomery   (2001)  RNAi and cosuppression: double-stranded RNA as an agent of sequence-specific genetic silencing in animal and plants in Molecular Biology of Double-stranded RNA:  Concepts and Applications in Agriculture, Forestry, and Medicine , S. M. Tavantzis, Ed. (pp. 1-36)  CRC Press: New York.
  4. Montgomery, MK and A Fire (1998)  Double-stranded RNA as a mediator in sequence-specific gene silencing and co-suppression.   Trends in Genetics   14:  255-258.
  5. Montgomery, MK and M McFall-Ngai (1994)   The inductive role of bacterial symbionts in the morphogenesis of a squid light organ.   American Zoologist   35: 372-380.

 

           

Non-Reviewed Scholarly Contributions

 

 

IV. PRESENTATIONS (^abstract published, undergraduate co-author, primary presenter )

 

Presentations at National or International Conferences

 

      Talks

 

  1. V Descotte and MK Montgomery “Differing susceptibilities to systemic RNAi within the Caenorhabditis clade” 14th International C. elegans Meeting (Los Angeles, CA) Jul 2003
  2. J Norman, E Bishop, and MK Montgomery "Potential for cross-interference with RNAi" 13th International C. elegans Meeting (Los Angeles, CA)  Jun 200
  3. MK Montgomery and A Fire “Regulation of maternal mRNA activity” Eleventh International C. elegans Meeting (Madison, WI) Jun 1997
  4. Invited speaker for symposium entitled “The Role of Cell-Cell Interactions and Environmental Stimuli in the Development of Marine Invertebrates and Animals”   Annual Meeting of the American Society of Zoologists (currently Society for Integrative and Comparative Biology) (Los Angeles, CA) 1993
  5. ^MK Montgomery and M McFall-Ngai “Embryological development of a squid symbiotic light organ” Annual Meeting of American Society of Zoologists (Atlanta, GA)   (American Zoologist 32: 80A)  1992
  6. ^MK Montgomery and M McFall-Ngai “The influence of bacterial symbionts on the early morphogenesis of the light organ of the sepiolid squid, Euprymna scolopes ” Annual Meeting of the American Society of Zoologists (Vancouver, BC) (American Zoologist 31:14A)   1991
  7. ^MK Montgomery and P Kremer “Direct transmission of algal symbionts through the sexual cycle of the host scyphozoan, Linuche unguiculata  Annual Meeting of the American Society of Zoologists (Boston, GA) (American Zoologist 29: 146A) 1989

 

      Posters

  1. ^V Descotte and MK Montgomery “Differing susceptibilities to systemic RNAi within the Caenorhabditis clade” 62nd Annual Meeting of the Society for Developmental Biology (Boston, MA) Aug 2003
  2. ^MK Montgomery “Collaborative research with undergraduate students: an assembly line model”   61 st Annual Meeting of the Society for Developmental Biology (Madison, WI) (Dev Biol 247:441) Jul 2002
  3. MK Montgomery “Differing susceptibilities to systemic RNAi within the Caenorhabditis clade”  European C. elegans Meeting (Paestum, Italy) May 2002 Also presented at the 13 th International C. elegans Meeting (Los Angeles, CA) Jun 2001
  4. ^ J Norman, E Bishop, and MK Montgomery "Potential for cross-interference with RNAi"
    60th Annual Meeting of the Society for Developmental Biology (Seattle, WA) (Dev Biol
    235: 234) Jul 2001
  5. ^ G. Padilla , S. Goetz , MK Montgomery "Tools for nematode evodevo studies"
    60th Annual Meeting of the Society for Developmental Biology (Seattle, WA) (Dev Biol
    235: 234) Jul 2001
  6. ^MK Montgomery “Breaking out of the model paradigm: using the comparative approach in undergraduate investigative labs”   59 th Annual Meeting of the Society for Developmental Biology (Boulder, CO)  (Dev Biol 222: 234) Jun 2000
  7. ^J Norman , E Bishop , and MK Montgomery “Using RNAi to study SKN-1 and other homologs governing early nematode development”   59th Annual Meeting of the Society for Developmental Biology (Boulder, CO) (Dev Biol 222: 237) Jun 2000
  8. ^MK Montgomery “Lecture/lab combo:  P-granule immunostaining in C. elegans   58th Annual Meeting of Society for Developmental Biology (Charlottesville, VA) Jun 1999
  9. ^K Galey, J Norman and MK Montgomery “The   ‘minimal dsRNA unit’ needed for RNAi in nematodes” 58th Annual Meeting of Society for Developmental Biology (Charlottesville, VA) Jun 1999
  10. J Norman , K Galey, and MK Montgomery “RNAi: how low can you go?”  
    Twelfth International C. elegans
    Meeting (Madison, WI) Jun 1999

 

     

Workshops

 

 

Presentations at Regional Conferences

 

      Talks

 

  1. MK Montgomery and A Fire “RNAi: the mystery continues to unfold” 1998 MidWest C. elegans Meeting (Chicago, IL) Jun 1998
  2. Invited speaker for symposium entitled “Influences of Bacteria on Development in Higher Plants and Animals”   West Coast Developmental Biologists Meeting Mar 1993

 

      Posters

  1. J Norman, E Bishop , and MK Montgomery “Using RNAi to study SKN-1 and other homologs governing early nematode development” 2000 MidWest C. elegans Meeting (Minneapolis, MN) Jun 2000
  2. MK Montgomery , K Galey , and J Norman “Using RNAi to study maternal gene function in ‘non-model’ nematodes”   The Developmental Basis of Evolutionary Change (U of Chicago)  May 1999
  3. MK Montgomery and A Fire “Analysis of posttranscriptional regulation in the early embryo” East Coast C. elegans Meeting (Rutgers U., NJ)  Jun 1996

 

      Workshops

 

 

Invited Lectures

 

  1. “Repression of gene activity using double-stranded RNA (RNAi): Evolutionary conservation and diversification in mechanism and function” University of Koln, Germany Apr 2002
  2. “Repression of gene activity using double-stranded RNA (RNAi): Evolutionary conservation and diversification in mechanism and function” University of Dusseldorf, Germany May 2002
  3. “Stop making sense: RNAi and gene silencing”   St. Olaf College, MN Mar 2002
  4. “RNAi: silencing genes both naughty and nice”   Carleton College, MN Oct 2001
  5. “RNAi: faster, cheaper, better?”   Oregon State University, OR Feb 2001
  6. “Use of transgene reporters to study gene expression”   C. elegans course, Cold Spring Harbor Laboratories, NY Nov 1999
  7. University of Colorado Medical School, Denver, CO (invited by graduate students in the Molecular Biology Program for annual symposium, “Reversing into the Future:   Functional Genomics and RNA Interference in Flies and Worms”) May 1999

 

 


V. AWARDS, RECOGNITION, AND GRANTS

 

External Grants 

 

                        Internal Support

 

 

Support for Post-Doctoral and Graduate Work

 
Undergraduate Awards and Scholarships



VI. TEACHING

 

1998-present   Macalester College, St. Paul, MN.

 

Courses Taught

 

      First Year Seminars

      The Unity and Diversity of Life

      Genetics

 

      Introductory Courses

      Cell Biology

      Genetics

 

      Intermediate Courses

      Developmental Biology

 

      Advanced Courses

      Research in Developmental Biology/Molecular Genetics

      Seminar in Molecular Evolution

 

Fall 1997         Johns Hopkins University

 

      Undergraduate Seminar: The Evolution of Developmental Mechanisms

 

Honors Research Advisor

 

Research performed in my laboratory:

2003    Veronica Descotte    Thesis:  Characterization of the RNA interference response within the Caenorhabditis clade
       (Graduate program in Molecular, Cellular, Developmental Biology, and Genetics, University of Minnesota)
2001    Sarah Goetz    Thesis: Evolution of the developmental determinant skn-1 in nematodes
       (Graduate program in Molecular, Cell, and Developmental Biology, University of North Carolina, Chapel Hill)
2000    Jeff Norman    Thesis: Utilizing the reverse genetic technique RNA interference to study homologous gene function in the nematodes C. elegans and C. briggsae
       (MD program, University of Minnesota)

 

Research  performed at another institution:

2002    Whitney Smalley          Thesis: The role of EP2 in pregnancy in mice

                                              


Summer Research Advisor

 

Summer 1999                          Jeff Norman (’00)

                                                Erin Bishop (’01)

                                                Adam Hankins (’01)

                                                Chinelo Njaka (’01)

                                                Emi Baldoni (’02)

 

Summer 2000                          Erin Bishop (’01)

                                                Sarah Goetz (’01)

                                                Jeremy Jensen (’02)

                                                Garett Padilla (’03)

 

Summer 2001                          Garett Padilla (’03)

                                                Osamudiame Uzzi (’04)

 

Summer 2003                          Meghan Cagley (’04)

                                                Holly Swanson (’04)

                                                Rachael Harlos (’06)

 

 

VII. SERVICE

 

Membership in Professional Societies

 

Genetics Society of America

Society for Developmental Biology

Council on Undergraduate Research

 

Professional Service


Ad hoc reviewer for the following:

      National Science Foundation                                                                                                         

      National Institutes of Health                                                                                                          

      USDA                                                                                                                                           

      Murdock College Research Program for Life Sciences                                                                  

 

I have reviewed articles for the following journals:

      Developmental Biology

      Genetics

      Marine Biology

      Journal of the Marine Biological Association of the United Kingdom

 

Community Service

 

Judge for Ramsey Junior High Science Fair                                                                        Nov 2002

Judge for undergraduate oral presentations at Annual Meeting of

      the Minnesota Academy of Science                                                                                        1999     

 

 

Macalester College Service

 

Educational Policy and Governance Committee                                                    elected Spring 2003

Health Professions Advisory Committee                                                                        2002-present

Jardetzky Lectureship Committee                                                                                   2001-present

Lilly Grant Symposium Committee                                                                                             2003

Public Scholarship for Social Change Working Group                                                               2003

BioMath Curriculum Committee                                                                                            2001-02

Representative for the ACM Committee on Women’s Concerns                                                 2001

Biology Department Search Committee for position in Plant Biology                                        2000

Biology Department Search Committee for position in Biochemistry                                          1999

Biology Search Committee for position in Animal Physiology                                                    1999

Biology Search Committee for Ordway Naturalist                                                                       1999

Women and Genders Studies Steering Committee                                                             1999-2001

Hughes Science Summer Institute                                                                  1999, 2000, 2001, 2003

      (contributed to program by being a research mentor, academic advisor, and participant in several workshops)