Visiting Assistant Professor
Psychology & Neuroscience
Olin-Rice Science Center, 324
Postdoctoral Fellow: National Institute of Neurological Disorders and Stroke
Ph.D. in Neuroscience: University of Pennsylvania Institute of Neuroscience
B.A. Double Major – Chemistry and Biology & Society: Cornell University
Dr. Kreiss’ research concerns animal models of Obsessive Compulsive Disorder (OCD). Current pharmacological treatments for OCD are problematic in that they take 8-10 weeks to work and only help about half the patients. Through examination of rat behaviors which mimic aspects of OCD symptomology, Dr. Kreiss’ research team hopes to add to the understanding of the neuronal dysfunction that underlies OCD and to facilitate the development of new therapeutic avenues for the treatment of this debilitating disorder that are more effective and quicker acting.
Brain, Mind and Behavior (NEURO/PSYC 180)
Seminar on Neurobiology of Anxiety and Depression (PSYC 394)
Advanced Methods in Behavioral Neuroscience (NEURO/PSYC 248)
Kreiss DS and De Deurwaerdère, P (2017) Purposeless oral activity induced by meta-chlorophenylpiperazine (m-CPP): undefined tic-like behaviors? Journal of Neuroscience Methods. pii: S0165-0270(17)30126-7
Kreiss DS, *Coffman CF, *Fiacco NR, *Granger JC, *Helton BM, *Jackson JC, *Kim LV, *Mistry RS, *Mizer TM, *Palmer LV, *Vacca JA, *Winkler SS, and *Zimmer BA (2013) Ritualistic Chewing Behavior induced by mCPP in the rat is an animal model of Obsessive Compulsive Disorder. Pharmacology, Biochemistry and Behavior 104:119–124. * denotes student authors
Allers KA, Bergstrom DA, Ghazi LJ, Kreiss DS, and Walters JR (2005). MK801 and amantadine exert different effects on subthalamic neuronal activity in a rodent model of Parkinson’s disease. Experimental Neurology 191: 104-118.
Kreiss DS, Mastropietro CW, Rawji SS, and Walters JR (1997) The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson’s disease. Journal of Neuroscience. 17:6807-6819.
Kreiss DS and Lucki I. (1994) Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Journal of Pharmacology and Experimental Therapeutics. 269:1268-1279.
*Davis CC, *Singerman KW, *Belforti SJ, *Ferrero AK, *Wubah AA and Kreiss DS (2017) Who’s Your Daddy? Transgenerational epigenetic effects of the neonatal clomipramine exposure rodent model of Obsessive Compulsive Disorder. Society for Neurosciences Conference. Washington, D.C.
*Stephens JL, *Chartampelia E, *Dangler AT, *Ellis ED, *Palmatary HL, and Kreiss DS (2017) Compared to male rats, female rats display increased OCD-like compulsive behaviors in the Hole Board and Marble Arena and decreased anxiety behaviors in the Elevated Plus Maze. Society for Neurosciences Conference. Washington, D.C.
*Alyssa C. Bower, * Thomas J. Agostini, * Zachary M. Brandt, * Kate A. Dalia, * Margaret K. Guignon, * Christian Kim, * Makena K. Rakouska, * Elizabeth H. Spruill, * Elissavet Chartampila, * Camilla C. Davis, and Deborah S. Kreiss (2017) Effects of Enrichment on Anxiety-Like and Compulsive-Like Behaviors in an Animal Model of Obsessive Compulsive Disorder (OCD). Faculty for Undergraduate Neuroscience Conference. Washington, D.C.
*Lockhart SR, *Marinaro DD, and Kreiss DS (2016) Effects of environment on behaviors in the elevated plus maze, marble arena, and hole board in the neoclomipramine rodent model of Obsessive Compulsive Disorder. Society for Neurosciences Conference, San Diego, CA.
*Laiks LS, *Barnes AM, *Gronseth EC, *Solin AM, *Burke L, *Kasparson LJ, *Matthijssen C, *Scalzo A, and Kreiss DS (2015) Comparison of behaviors under Light versus Dark conditions in the neoclomipramine rodent model of Obsessive Compulsive Disorder (OCD). Society for Neurosciences Conference, Chicago, IL.
Kreiss DS, *Frank SE, *Craig KM, *Mulder HS, *Hyde AL, and *Laiks LS (2014) Neonatal exposure to clomipramine is a behavioral rat model of Obsessive Compulsive Disorder offering face validity as well as predictive validity for the GABA agonist diazepam, the serotonin uptake inhibitor fluoxetine, and the norepinephrine uptake inhibitor desipramine. Society for Neurosciences Conference, Washington, D.C.
* denotes student authors