Methamphetamines: An Overview

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Introduction Meth Homepage Biochemistry Neurotoxicity Physiological Effects Residual Effects Therapeutic Use

Baicy, K. and London, E. (2007). Corticolimbic dysregulation and chronic methamphetamine abuse. Addiction, 102, p. 5-15.

Belcher, A., O”Dell, S., & Marshall, J.F. (2005). Impaired Object Recognition Memory Following Methamphetamine, but not p-Chloroamphetamine- or d-Amphetamine-Induced Neurotoxicity. Neuropsychopharmacology, 30, pp. 2026-2034.

Block, M. L., Zecca, L. & Hong, J. (January 2007). Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience, (8), 57-69.

Buffenstein, A., Heaster, J., and Ko, P. (1999). Chronic psychotic illness from methamphetamine. American Journal of Psychiatry, 156, p. 662.

Carlson, N. R. (2007). Physiology of Behavior: Ninth Edition. Boston: Pearson Education, Inc.

Center for Disease Control and Prevention. (5/22/2007).

Chang, L., Alicata, D., Ernst, T., and Volkow, N. (2007). Structural and metabolic brain changes in the striatum associated with methamphetamine abuse. Addiction, 102, p. 16-32.

Cho, A. K., Melega, W. P. (2002). Patterns of methamphetamine abuse and their consequences. Journal of Addictive Diseases,21, 21–34.

Cook, J. D. and Schanberg, S. M. (1975). Effect of methamphetamine on norepinephrine metabolism in various regions of brain. Journal of Pharmacology and Experimental Therapeutics, 195, 87-93.

Cooper, J. R., Bloom, F. E., and Roth, R. H. (1982). The Biochemical Basis of Neuropharmacology: Fourth edition. New York: Oxford University Press.

FRONTLINE (PBS). How Meth Destroys the Body.

Fumagalli, F., Gainetdinov, R. R., Valenzano, K. J., Caron, M.G. (1998). Role of dopamine transporter in methamphetamine-induced neurotoxicity: Evidence from mice lacking the transporter. Journal of Neuroscience, 18, 4861–4869.

Gahlinger, P. (2004). Illegal Drugs: A Complete Guide to their History, Chemistry, Use, and Abuse. P. 204-221. London, England: Penguin Books.

Green, A.I. & Halkitis, P.N. (2006). Crystal methamphetamine and sexual sociality in an urban gay subculture: An elective affinity. Culture, Health & Sexuality, 8(4), 317-333.

Holland, E. (2002). Methamphetamine drastically increases virus’ ability to replicate in brain tissue. Ohio State Research.

Homer, B., Solomon, T., Moeller, R., Mascia, A., DeRaleau, L., and Halkitis, P. (2008). Methamphetamine abuse and impairment of social functioning: A review of the underlying neuropsychological causes and behavioral implications. Psychological Bulletin, 134, p. 301-310.

Iyo, M., Sekine, Y., and Mori, N. (2004). Neuromechanism of developing methamphetamine psychosis: A neuroimaging study. In Ali, S., Nabeshima, T., and Yanagita, T. (2004). Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity. 1025, p. 288-295. New York, NY, US: New York Academy of Sciences.

Johanson, C.E., Frey, K., Lundahl, L., Keenan, P., Lockhart, N., Roll, J., Galloway, G., Koeppe, R., Kilbourn, M., Robbins, T., and Schuster, C. (2006). Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers. Psychopharmacology, 186, p. 620.

Kuczenski, R., Segal, D. S., Cho, A.K., and Melega, W. (1995). Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine. Journal of Neuroscience, 15,1308–1317.

Larsen, K. E., Fon, E. A., Hastings, T. G., Edwards, R. H., & Sulzer, D. (2002). Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. Journal of Neuroscience, 22(20), 8951-8960.

Leonard, B. E. (1997). Fundamentals of Psychopharmacology: Second Edition. Chichester, England: John Wiley & Sons Ltd.

Little, B.B., Snell, L.M., & Gilstrap, L.C. 3rd. (1988). Methamphetamine abuse during pregnancy: outcome and fetal effects. Obstetrics & Gynecology, 72 (4), pp. 541-544

London, E., Simon, S., Berman, S., Mandelkern, M., Lichtman, A., Bramen, J., Shinn, A., Miotto, K., Learn, J., Dong, Y., Matochik, J., Kurian, V., Newton, T., Woods, R., Rawson, R., and Ling, W. (2004). Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Archives of General Psychiatry, 61, p. 78-84.

London, E.D., Berman, S.M., Voytek, B., Simon, S.L., Mandelkern, M.A., Monterosso, J., Thompson, P.M., Brody, A.L., Geaga, J.A., Hong, M.S., Hayashi, K.M. Rawson, R.A., & Ling, W. (2005). Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Biological Psychiatry, 58 (10), pp. 770-778.

Monson, Kristi. (2007). Methamphetamine and Weight Loss. eMedTV. http://mental-

Marshall, J., Belcher, A., Feinstein, E., and O’Dell, S. (2007). Methamphetamine-induced neural and cognitive changes in rodents. Addiction, 102, p. 61-69.

Mitler MM, Hajdukovic R, Erman MK (1993). “Treatment of narcolepsy with methamphetamine”. Sleep 16(4): 306-17.

National Institute on Drug Abuse. Methamphetamine abuseand addiction [Research Report series] (1998).

National Institutes of Health. (3/1/2001). Methamphetamine Abuse Leads to Long-Lasting Changes in the Human Brain that are Linked to Impaired Coordination and Memory. American Journal of Psychiatry, 158 (3), pp. 383-389.

National Institutes of Health. (8/11/2005). Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure.

National Institute of Mental Health. (4/3/2008). Attention Deficit-Hyperactivity Disorder (ADHD). Nordahl, T., Salo, R., and Leamon, M. (2003). Neuropsychological effects of chronic methamphetamine use on neurotransmitters and cognition: A review. The Journal of Neuropsychiatry and Clinical Neurosciences, 15, p. 317-325.

O’Connor, A. (2/22/2005). Scientists Explore Meth’s Role in Immune System. The New York Times, Health.

Perrine, D. M. (1996). The Chemistry of Mind-Altering Drugs: History, Pharmacology, and Cultural Context. Washington, DC: American Cancer Society.

Richards, JB., Sabol KE.,de Wit H. (1999) Effects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats. Psychopharmacology 146(4):432-9

Riddle, E. L., Fleckenstein, A. E. & Hanson, G. R. (June 16, 2006). Mechanisms of Methamphetamine-induced Dopaminergic Neurotoxicity. The AAPS Journal, 2(8).

Salo, R., Nordahl, T., Natsuaki, Y., Leamon, M., Galloway, G., Waters, C., Moore, C., and Buonocore, M. (2007). Attentional control and brain metabolite levels in methamphetamine abusers. Biological Psychiatry, 61, p. 1272-1280.

Schmidt, C. J., Ritter, J. K., Sonsalla, P. K., Hanson, G. R., and Gibb, J. W. (1985). Role of dopamine in the neurotoxic effects of methamphetamine. Journal of Pharmacology and Experimental Therapeutics, 233, 539–544.

Schröder, N., O’Dell, S.J., & Marshall, J.F. (2003). Neurotoxic methamphetamine regimen severely impairs recognition memory in rats. Synapse, 49 (2), 89-96.

Seiden, L.S., Fischman, M.W., and Schuster, C.R. (1975/76). Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys. Drug and Alcohol Dependence 1, 215-219.

Sekine, Y., Minabe, Y., Kawai, M., Suzuki, K., Iyo, M., Isoda, H., Sakahara, H., Ashby, C., Takei, N., and Mori, N. (2002). Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms: A proton MRS study. Neuropsychopharmacology, 27, p. 453-461.

Sekine, Y., Minabe, Y., Ouchi,Y., Takei, N., Iyo, M., Nakamura, K., Suzuki, K., Tsukada, H., Okada, H., Yoshikawa, E., Futasubashi, M., and Mori, N. (2003). Association of Dopamine Transporter Loss in the Orbitofrontal and Dorsolateral Prefrontal Cortices with Methamphetamine-related Psychiatric Symptoms. American Journal of Psychiatry, 160, p. 1699-1701.

Sekine, Y., Ouchi, Y., Takei, N., Yoshikawa, E., Nakamura, K., Futatsubashi, M., Okada, H., Minabe, Y., Suzuki, K., Iwata, Y., Tsuchiya, K., Tsukada, H., Iyo M., and Mori, N. (2006). Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Archives of General Psychiatry, 63, p. 90-100.

Shoblock J. R., Maisonneuve I. M., and Glick S. D. (2004). Differential interactions of desipramine with amphetamine and methamphetamine: Evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex. Neurochemical Research, 29, 1437-1442.

Solanto, MV. “Clinical psychopharmacology of AD/HD: implications for animal models”. (200). Neurosci Biobehav Rev 24(1): 27-30.

Sonsalla, P. K., Gibb, J. W., and Hanson, G. R. (1986). Roles of D1 and D2 dopamine receptor subtypes in mediation of methamphetamine-induced changes in monamine systems. Journal of Pharmacology and Experimental Therapeutics, 238, 932–937.

Spiller, M.S. (2000). Meth Mouth.

Volkow, N. D., Chang, L., Wang, G., Fowler, J. S., Leonido-Yee, M., Franceschi, D., Sedler, M. J., Gatley, S. J., Hitzemann, R., Ding, Y. (2001). Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. American Journal of Psychiatry, 158, 377-382.

Volkow, N., Chang, L., Wang, G.J., Fowler, J., Franceschi, D., Sedler, M., Gatley, S., Hitzemann, R., Ding, Y.S., Wong, C., and Logan, J. (2001). Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. American Journal of Psychiatry, 158, p. 383-389.

Volkow, N. D., Chang, L., Wang, G., Fowler, J. S., Ding, Y., Sedler, M., Logan, J., Franceshi, D., Gatley, J., Hitzemann, R., Gifford, A., Wong, C., and Pappas, N. (2001). Low level of brain dopamine d2 receptors in methamphetamine abusers: Association with metabolism in the orbitofrontal cortex. American Journal of Psychiatry, 158, 2015-2021.

Vorhees, C.V., Ahrens, K.G., Acuff-Smith, K.D., Schilling, M.A. & Fisher, J.E. (1994). Methamphetamine exposure during early postnatal development in rats: I. Acoustic startle augmentation and spatial learning deficits. Psychopharmacology, 114 (3), 392-401.

Wang, Y., Chou, J., Jeng, C. H., Morales, M., and Wang, J. Y. (2000). Chronic methamphetamine exposure decreases high affinity uptake function in norepinephrine afferents in the cerebellar cortex: An electrophysiological and electrochemical study. Neuropharmacology, 39, 2112-2123.

Wells, K. Methamphetamine and Pregnancy. Denver Family Crisis Center.

Williams, M.T., Brown, R.W. & Vorhees, C.V. (2004). Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens and parietal cortex. European Journal of Neuroscience, 19, 3165-3170.

Yu, Q., Larson, D.F., & Watson, R.R. (2003). Heart disease, methamphetamine and AIDS. Life Science, 73 (2), pp. 129-140.

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